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Integrated sudomotor axon reflex sweat stimulation for continuous sweat analyte analysis with individuals at rest

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Abstract

Eccrine sweat has rapidly emerged as a non-invasive, ergonomic, and rich source of chemical analytes with numerous technological demonstrations now showing the ability for continuous electrochemical sensing. However, beyond active perspirers (athletes, workers, etc.), continuous sweat access in individuals at rest has hindered the advancement of both sweat sensing science and technology. Reported here is integration of sudomotor axon reflex sweat stimulation for continuous wearable sweat analyte analysis, including the ability for side-by-side integration of chemical stimulants & sensors without cross-contamination. This integration approach is uniquely compatible with sensors which consume the analyte (enzymatic) or sensors which equilibrate with analyte concentrations. In vivo validation is performed using iontophoretic delivery of carbachol with ion-selective and impedance sensors for sweat analysis. Carbachol has shown prolonged sweat stimulation in directly stimulated regions for five hours or longer. This work represents a significant leap forward in sweat sensing technology, and may be of broader interest to those interested in on-skin sensing integrated with drug-delivery.

Graphical abstract: Integrated sudomotor axon reflex sweat stimulation for continuous sweat analyte analysis with individuals at rest

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Publication details

The article was received on 03 Apr 2017, accepted on 26 Jun 2017 and first published on 04 Jul 2017


Article type: Paper
DOI: 10.1039/C7LC00364A
Citation: Lab Chip, 2017, Advance Article
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    Integrated sudomotor axon reflex sweat stimulation for continuous sweat analyte analysis with individuals at rest

    Z. Sonner, E. Wilder, T. Gaillard, G. Kasting and J. Heikenfeld, Lab Chip, 2017, Advance Article , DOI: 10.1039/C7LC00364A

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