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Hybrid polymer microfluidic platform to mimic varying vascular compliance and topology

Abstract

Several cardiovascular pathologies and aging have been associated with alterations in mechanical and structural properties of vascular wall, leading to reduction in arterial compliance and development of constriction. In the past, rare efforts have been directed to understand the endothelial cell response to combined mechanical stimuli from fluid flow and substrate rigidity. Recent approaches using microfluidic platforms have limitations in precisely mimicking the healthy and diseased vasculature conditions from altered topological and substrate compliance perspective. To address this need, we demonstrate an effective fabrication process to realize a hybrid polymer platform to test such mechanistic features of blood vessels. Salient features of the platform include circular microchannels of varying diameters and variation in substrate rigidity along the channel length, and coexistence of microchannels with different cross sections on a single platform. The platform demonstrates the combined effects of flow-induced shear forces and substrate rigidity on endothelial cell layer inside the circular microchannels. Experimental results indicate pronounced cell response to flow induced shear stress via the interplay with the underlying substrate mechanics.

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Supplementary files

Publication details

The article was received on 28 Mar 2017, accepted on 06 Jun 2017 and first published on 07 Jun 2017


Article type: Paper
DOI: 10.1039/C7LC00340D
Citation: Lab Chip, 2017, Accepted Manuscript
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    Hybrid polymer microfluidic platform to mimic varying vascular compliance and topology

    M. L. Rathod, J. Ahn, N. L. Jeon and J. Lee, Lab Chip, 2017, Accepted Manuscript , DOI: 10.1039/C7LC00340D

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