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A novel wireless paper-based potentiometric platform for monitoring glucose in blood


A novel low-cost, compact and sensitive paper-based platform for the accurate monitoring of glucose in biological fluids is presented. Paper-based working and reference electrodes are combined to build a whole potentiometric cell, which also fits a sampling module for the simple and fast determination of glucose in a single drop of blood. The working electrode is built using a platinized filter paper coated with Nafion membrane that entraps the enzyme glucose oxidase; the reference electrode is made by casting a polyvinylbutyral-based membrane onto a conductive paper. The system works by detecting the hydrogen peroxide generated as a result of the enzymatic reaction. Selectivity is achieved due to the permselective behaviour of Nafion, while a significant enhancement of the sensitivity is reached by exploiting the Donnan-coupled formal potential. Under optimum conditions, a sensitivity of -95.9 ± 4.8 mV/decade in the 10-2.5 to 10-3.5 M range is obtained. Validation of the measurements has been performed against standard methods in human serum and blood. Final integration with a wireless reader allows for truly in situ measurements with less than 2-minute procedure including a two-point calibration, washing and measurement. This low-cost analytical device opens up new prospects for rapid diagnostic results in non-laboratory settings.

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Publication details

The article was received on 28 Mar 2017, accepted on 16 May 2017 and first published on 14 Jun 2017

Article type: Paper
DOI: 10.1039/C7LC00339K
Citation: Lab Chip, 2017, Accepted Manuscript
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    A novel wireless paper-based potentiometric platform for monitoring glucose in blood

    R. Cánovas, M. Parrilla, P. Blondeau and F. J. J. Andrade, Lab Chip, 2017, Accepted Manuscript , DOI: 10.1039/C7LC00339K

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