Jump to main content
Jump to site search

Issue 13, 2017
Previous Article Next Article

Effects of diffusion and mixing pattern on microfluidic-assisted synthesis of chitosan/ATP nanoparticles

Author affiliations

Abstract

Chitosan (CHI) nanoparticles present promising applications in pharmaceutical and biomedical fields, including drug and gene delivery. Among different approaches, microfluidics emerges as a resourceful tool for nanoparticle production in low-cost, reproducible processes with predictable fluid dynamics. However, microfluidic-assisted synthesis of CHI nanoparticles has not been widely explored in the literature. In this context, we systematically investigated different process parameters that influence the synthesis of CHI/ATP nanoparticles. We highlight the effects and limitations of diffusion and distinct mixing patterns developed through the microchannels on the final physicochemical characteristics of CHI/ATP nanoparticles produced. To address these hurdles, here we describe a simple, feasible, and reproducible method for the production of CHI/ATP nanoparticles. This strategy enables the development of a continuous and homogeneous production process for CHI nanoparticles to be applied in the most varied fields of research.

Graphical abstract: Effects of diffusion and mixing pattern on microfluidic-assisted synthesis of chitosan/ATP nanoparticles

Back to tab navigation

Supplementary files

Publication details

The article was received on 18 Mar 2017, accepted on 29 May 2017 and first published on 01 Jun 2017


Article type: Paper
DOI: 10.1039/C7LC00291B
Citation: Lab Chip, 2017,17, 2281-2293
  •   Request permissions

    Effects of diffusion and mixing pattern on microfluidic-assisted synthesis of chitosan/ATP nanoparticles

    A. C. S. N. Pessoa, C. C. Sipoli and L. G. de la Torre, Lab Chip, 2017, 17, 2281
    DOI: 10.1039/C7LC00291B

Search articles by author

Spotlight

Advertisements