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Open-channel, water-in-oil emulsification in paper-based microfluidic devices

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Abstract

Open-channel microfluidic devices have shown great potential in achieving a high degree of fluid control, at relatively low-cost, while enabling the opportunity for rapid fabrication. However, thus far, work in open channel microfluidics has largely focused on controlling the flow of water or other aqueous solutions. In this work we present new open channel microfluidic devices based on surfaces with patterned wettabilty that are capable of controlling the flow of virtually all high and low surface tension liquids. The fabricated open channel devices are capable of constraining a variety of low surface tension oils at high enough flow rates to enable, for the first time, water-in-oil microfluidic emulsification in an open channel device. By changing the flow rates for both the aqueous (dispersed) and organic (continuous) phases, we show that it is possible to vary the size of the emulsified droplets produced in the open channel device. Finally, we utilized the fabricated devices to synthesize relatively monodisperse, hydrogel microparticles that could incorporate a drug molecule. We also investigated the drug release characteristics of the fabricated particles.

Graphical abstract: Open-channel, water-in-oil emulsification in paper-based microfluidic devices

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Publication details

The article was received on 03 Feb 2017, accepted on 10 Mar 2017, published on 10 Mar 2017 and first published online on 10 Mar 2017


Article type: Communication
DOI: 10.1039/C7LC00114B
Citation: Lab Chip, 2017, Advance Article
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    Open-channel, water-in-oil emulsification in paper-based microfluidic devices

    C. Li, M. Boban and A. Tuteja, Lab Chip, 2017, Advance Article , DOI: 10.1039/C7LC00114B

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