Jump to main content
Jump to site search


An intravascular bioartificial pancreas device (iBAP) with silicon nanopore membranes (SNM) for islet encapsulation under convective mass transport

Author affiliations

Abstract

Diffusion-based bioartificial pancreas (BAP) devices are limited by poor islet viability and functionality due to inadequate mass transfer resulting in islet hypoxia and delayed glucose–insulin kinetics. While intravascular ultrafiltration-based BAP devices possess enhanced glucose–insulin kinetics, the polymer membranes used in these devices provide inadequate ultrafiltrate flow rates and result in excessive thrombosis. Here, we report the silicon nanopore membrane (SNM), which exhibits a greater hydraulic permeability and a superior pore size selectivity compared to polymer membranes for use in BAP applications. Specifically, we demonstrate that the SNM-based intravascular BAP with ∼10 and ∼40 nm pore sized membranes support high islet viability (>60%) and functionality (<15 minute insulin response to glucose stimulation) at clinically relevant islet densities (5700 and 11 400 IE per cm2) under convection in vitro. In vivo studies with ∼10 nm pore sized SNM in a porcine model showed high islet viability (>85%) at clinically relevant islet density (5700 IE per cm2), c-peptide concentration of 144 pM in the outflow ultrafiltrate, and hemocompatibility under convection. These promising findings offer insights on the development of next generation of full-scale intravascular devices to treat T1D patients in the future.

Graphical abstract: An intravascular bioartificial pancreas device (iBAP) with silicon nanopore membranes (SNM) for islet encapsulation under convective mass transport

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 28 Jan 2017, accepted on 12 Apr 2017 and first published on 13 Apr 2017


Article type: Paper
DOI: 10.1039/C7LC00096K
Citation: Lab Chip, 2017, Advance Article
  •   Request permissions

    An intravascular bioartificial pancreas device (iBAP) with silicon nanopore membranes (SNM) for islet encapsulation under convective mass transport

    S. Song, C. Blaha, W. Moses, J. Park, N. Wright, J. Groszek, W. Fissell, S. Vartanian, A. M. Posselt and S. Roy, Lab Chip, 2017, Advance Article , DOI: 10.1039/C7LC00096K

Search articles by author