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Droplet control technologies for microfluidic high throughput screening (μHTS)

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Abstract

The transition from micro well plate and robotics based high throughput screening (HTS) to chip based screening has already started. This transition promises reduced droplet volumes thereby decreasing the amount of fluids used in these studies. Moreover, it significantly boosts throughput allowing screening to keep pace with the overwhelming number of molecular targets being discovered. In this review, we analyse state-of-the-art droplet control technologies that exhibit potential to be used in this new generation of screening devices. Since these systems are enclosed and usually planar, even some of the straightforward methods used in traditional HTS such as pipetting and reading can prove challenging to replicate in microfluidic high throughput screening (μHTS). We critically review the technologies developed for this purpose in depth, describing the underlying physics and discussing the future outlooks.

Graphical abstract: Droplet control technologies for microfluidic high throughput screening (μHTS)

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Publication details

The article was received on 02 Jan 2017, accepted on 08 Jun 2017 and first published on 09 Jun 2017


Article type: Critical Review
DOI: 10.1039/C7LC00005G
Citation: Lab Chip, 2017, Advance Article
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    Droplet control technologies for microfluidic high throughput screening (μHTS)

    M. Sesen, T. Alan and A. Neild, Lab Chip, 2017, Advance Article , DOI: 10.1039/C7LC00005G

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