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Multi-chamber microfluidic platform for high-precision skin permeation testing

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The established in vitro tool used for testing the absorption and penetration of chemicals through skin in pharmacology, toxicology and cosmetic science is the static Franz diffusion cell. While widespread, Franz cells are relatively costly, low-throughput and results may suffer from poor reproducibility. Microfluidics has the potential to overcome these drawbacks. In this paper, we present a novel microfluidic skin permeation platform and validate it rigorously against the Franz cell by comparing the transport of 3 model chemicals of varying lipophilicity: caffeine, salicylic acid and testosterone. Permeation experiments through silicone membranes show that the chip yields higher sensitivity in permeant cumulative amounts and comparable or lower coefficients of variation. Using a skin organotypic culture, we show that the chip decreases the effect of unstirred water layers that can occur in static Franz cells. The validation reported herein sets the stage for efficient skin permeation and toxicity screening and further development of microfluidic skin-on-chip devices.

Graphical abstract: Multi-chamber microfluidic platform for high-precision skin permeation testing

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Publication details

The article was received on 23 Dec 2016, accepted on 03 Apr 2017 and first published on 03 Apr 2017

Article type: Paper
DOI: 10.1039/C6LC01574C
Citation: Lab Chip, 2017, Advance Article
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    Multi-chamber microfluidic platform for high-precision skin permeation testing

    M. Alberti, Y. Dancik, G. Sriram, B. Wu, Y. L. Teo, Z. Feng, M. Bigliardi-Qi, R. G. Wu, Z. P. Wang and P. L. Bigliardi, Lab Chip, 2017, Advance Article , DOI: 10.1039/C6LC01574C

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