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Single Nanoparticle Analysis by ICPMS: A Potential Tool for Bioassay

Abstract

Inductively coupled plasma mass spectrometry (ICPMS) has already been demonstrated as a promising technique for metallic nanoparticle tagged bioassays, thanks to its high sensitivity, wide dynamic linear range, and more importantly multiplex and absolute quantification ability. Besides, single nanoparticle analysis by ICPMS has also recently been applied for many metal nanoparticles. Short dwell times (serval hundreds of microsecond) of data acquisition led to extremely high signal to noise ratio of metal nanoparticles (i.e., low detection limits). This perspective focus on the single nanoparticle analysis-based ICPMS bioassays, which provide high sensitivity without any sophisticated signal amplification procedure. In this perspective, the recent development of single nanoparticle analysis, ICPMS instrument design, and single molecule analysis was discussed. Considering vast kinds of metallic nanoparticles are currently available and simultaneously multiplex detection capability of TOF-ICPMS, the single nanoparticle analysis-based bioassay may open a new avenue for multiplex single molecule analysis.

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Publication details

The article was received on 27 Jun 2017, accepted on 13 Nov 2017 and first published on 13 Nov 2017


Article type: Perspective
DOI: 10.1039/C7JA00235A
Citation: J. Anal. At. Spectrom., 2017, Accepted Manuscript
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    Single Nanoparticle Analysis by ICPMS: A Potential Tool for Bioassay

    J. Hu, D. Deng, R. Liu and Y. Lv, J. Anal. At. Spectrom., 2017, Accepted Manuscript , DOI: 10.1039/C7JA00235A

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