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Biological network border detection

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Abstract

Complex networks have been widely used to model biological systems. The concept of accessibility has been proposed recently as a means to organize the nodes of complex networks as belonging to its border or center. Such an approach paves the way to investigating how the functional and structural properties of nodes vary with their respective position in the networks. In this work, we approach such a problem in a biological context applying border detection to Protein–Protein Interaction networks from four organisms of the Mycoplasma genus. We found evidence that the borderness of proteins bears a relation with their spatial organization and molecular function specificity.

Graphical abstract: Biological network border detection

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Publication details

The article was received on 12 Sep 2017, accepted on 31 Oct 2017 and first published on 01 Nov 2017


Article type: Paper
DOI: 10.1039/C7IB00161D
Citation: Integr. Biol., 2017, Advance Article
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    Biological network border detection

    P. E. P. Burke, C. H. Comin, F. N. Silva and L. D. F. Costa, Integr. Biol., 2017, Advance Article , DOI: 10.1039/C7IB00161D

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