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Issue 12, 2017
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High-frequency irreversible electroporation targets resilient tumor-initiating cells in ovarian cancer

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Abstract

We explored the use of irreversible electroporation (IRE) and high-frequency irreversible electroporation (H-FIRE) to induce cell death of tumor-initiating cells using a mouse ovarian surface epithelial (MOSE) cancer model. Tumor-initiating cells (TICs) can be successfully destroyed using pulsed electric field parameters common to irreversible electroporation protocols. Additionally, high-frequency pulses seem to induce cell death of TICs at significantly lower electric fields suggesting H-FIRE can be used to selectively target TICs and malignant late-stage cells while sparing the non-malignant cells in the surrounding tissue. We evaluate the relationship between threshold for cell death from H-FIRE pulses and the capacitance of cells as well as other properties that may play a role on the differences in the response to conventional IRE versus H-FIRE treatment protocols.

Graphical abstract: High-frequency irreversible electroporation targets resilient tumor-initiating cells in ovarian cancer

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Publication details

The article was received on 01 Jul 2017, accepted on 19 Nov 2017 and first published on 22 Nov 2017


Article type: Paper
DOI: 10.1039/C7IB00116A
Citation: Integr. Biol., 2017,9, 979-987
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    High-frequency irreversible electroporation targets resilient tumor-initiating cells in ovarian cancer

    A. Rolong, E. M. Schmelz and R. V. Davalos, Integr. Biol., 2017, 9, 979
    DOI: 10.1039/C7IB00116A

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