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A multiscale study of the role of dynamin in the regulation of glucose uptake

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Abstract

Glucose uptake in muscle cells in response to insulin is a fundamental mechanism for metabolism. The inability of cells to mobilize the specific glucose transporter GLUT4 is believed to be at least partially accountable for diseases, like diabetes, where cells do not respond to an insulin stimulus. In this work, a microchip is used to detect electrochemically glucose uptake from C2C12 myoblasts cultured on a patch of paper upon exposure to insulin. More importantly, the data suggest a new role for dynamin, a molecular motor which would be involved in GLUT4 translocation by facilitating exocytosis. It is also shown in vivo that dynamin is involved in the response to glucose in a completely distinct organism, namely the nematode Caenorhabditis elegans. The new mechanism for dynamin could therefore be more generally relevant in vivo and may play a role in insulin resistance.

Graphical abstract: A multiscale study of the role of dynamin in the regulation of glucose uptake

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Publication details

The article was received on 20 Jan 2017, accepted on 09 Aug 2017 and first published on 23 Aug 2017


Article type: Paper
DOI: 10.1039/C7IB00015D
Citation: Integr. Biol., 2017, Advance Article
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    A multiscale study of the role of dynamin in the regulation of glucose uptake

    R. Trouillon, M. C. Letizia, K. J. Menzies, L. Mouchiroud, J. Auwerx, K. Schoonjans and M. A. M. Gijs, Integr. Biol., 2017, Advance Article , DOI: 10.1039/C7IB00015D

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