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Chemical genomic analysis of GPR35 signaling

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Abstract

GPR35, a family A orphan G protein-coupled receptor, has been implicated in inflammatory, neurological, and cardiovascular diseases. However, not much is known about the signaling and functions of GPR35. We performed a label-free kinome short hairpin RNA screen and identified a putative signaling network of GPR35 in HT-29 cells, some of which was validated using gene expression, biochemical and cellular assays. The results showed that GPR35 induced hypoxia-inducible factor 1α, and was involved in synaptic transmission, sensory perception, the immune system, and morphogenetic processes. Collectively, our data suggest that GPR35 may play an important role in response to hypoxic stress and be a potential target for the treatment of inflammatory, cardiovascular, and neurological disorders.

Graphical abstract: Chemical genomic analysis of GPR35 signaling

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Publication details

The article was received on 07 Jan 2017, accepted on 31 Mar 2017 and first published on 06 Apr 2017


Article type: Paper
DOI: 10.1039/C7IB00005G
Citation: Integr. Biol., 2017, Advance Article
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    Chemical genomic analysis of GPR35 signaling

    H. (. Hu, H. Deng, S. Ling, H. Sun, T. Kenakin, X. Liang and Y. Fang, Integr. Biol., 2017, Advance Article , DOI: 10.1039/C7IB00005G

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