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Issue 3, 2017
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Super-resolution imaging of alpha-synuclein polymorphisms and their potential role in neurodegeneration

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Abstract

The conversion of soluble, functional proteins into amyloid fibrils has been linked to the development of neurodegenerative disorders, including Parkinson's and Alzheimer's disease. In the brains of patients with these disorders, the increasing presence of amyloid-containing plaques corresponds to neuronal cell death and the worsening of symptoms. However, protein amyloids are not merely confined to dying cells. Rather, some show a propensity to be transmitted to, and enter adjacent cells and induce the polymerization of the native monomer population. Whether this process is directly associated with toxicity or not is still highly debated. In this mini review, we will discuss structural polymorphisms of α-synuclein, as determined by super-resolution imaging techniques, and how these may be related to neuronal toxicity.

Graphical abstract: Super-resolution imaging of alpha-synuclein polymorphisms and their potential role in neurodegeneration

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Publication details

The article was received on 04 Oct 2016, accepted on 31 Jan 2017 and first published on 01 Feb 2017


Article type: Review Article
DOI: 10.1039/C6IB00206D
Citation: Integr. Biol., 2017,9, 206-210
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    Super-resolution imaging of alpha-synuclein polymorphisms and their potential role in neurodegeneration

    E. Nugent, C. F. Kaminski and G. S. Kaminski Schierle, Integr. Biol., 2017, 9, 206
    DOI: 10.1039/C6IB00206D

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