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Issue 1, 2017
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New insights into mammalian signaling pathways using microfluidic pulsatile inputs and mathematical modeling

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Abstract

Temporally modulated input mimics physiology. This chemical communication strategy filters the biochemical noise through entrainment and phase-locking. Under laboratory conditions, it also expands the observability space for downstream responses. A combined approach involving microfluidic pulsatile stimulation and mathematical modeling has led to deciphering of hidden/unknown temporal motifs in several mammalian signaling pathways and has provided mechanistic insights, including how these motifs combine to form distinct band-pass filters and govern fate regulation under dynamic microenvironment. This approach can be utilized to understand signaling circuit architectures and to gain mechanistic insights for several other signaling systems. Potential applications include synthetic biology and biotechnology, in developing pharmaceutical interventions, and in developing lab-on-chip models.

Graphical abstract: New insights into mammalian signaling pathways using microfluidic pulsatile inputs and mathematical modeling

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Publication details

The article was received on 29 Aug 2016, accepted on 26 Oct 2016 and first published on 15 Nov 2016


Article type: Review Article
DOI: 10.1039/C6IB00178E
Citation: Integr. Biol., 2017,9, 6-21
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    New insights into mammalian signaling pathways using microfluidic pulsatile inputs and mathematical modeling

    M. Sumit, S. Takayama and J. J. Linderman, Integr. Biol., 2017, 9, 6
    DOI: 10.1039/C6IB00178E

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