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Towards sustainable kinetic resolution, a combination of bio-catalysis, flow chemistry and bio-based solvents

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Abstract

The esterification of 2-phenylpropionic acid was investigated as a model system for enzyme catalysed (CALB, Novozyme 435) reactions in bio-based solvents. A multi-parameter correlation taking into account solvent parameters was developed to explain experimental observations. A continuous flow process using p-cymene as the solvent was operated over several weeks, thus combining a sustainable solvent and flow chemistry for kinetic resolution.

Graphical abstract: Towards sustainable kinetic resolution, a combination of bio-catalysis, flow chemistry and bio-based solvents

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Publication details

The article was received on 21 Oct 2017, accepted on 30 Nov 2017 and first published on 01 Dec 2017


Article type: Communication
DOI: 10.1039/C7GC03177G
Citation: Green Chem., 2018, Advance Article
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    Towards sustainable kinetic resolution, a combination of bio-catalysis, flow chemistry and bio-based solvents

    A. Iemhoff, J. Sherwood, C. R. McElroy and A. J. Hunt, Green Chem., 2018, Advance Article , DOI: 10.1039/C7GC03177G

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