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A catalyst-free, waste-less ethanol-based solvothermal synthesis of amides

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Abstract

A green, one-pot approach based on the solvothermal amidation of carboxylic acids with amines has been developed for the synthesis of diverse aliphatic and aromatic amides. It does not require the use of catalysts or coupling reagents and it occurs in the presence of ethanol that has been proved to have a key role in the process. The proposed strategy is also extendable to biologically active amides and could represent a low-cost and waste-less alternative to the common synthetic pathways.

Graphical abstract: A catalyst-free, waste-less ethanol-based solvothermal synthesis of amides

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Publication details

The article was received on 02 Oct 2017, accepted on 01 Dec 2017 and first published on 04 Dec 2017


Article type: Communication
DOI: 10.1039/C7GC02967E
Citation: Green Chem., 2018, Advance Article
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    A catalyst-free, waste-less ethanol-based solvothermal synthesis of amides

    F. Dalu, M. A. Scorciapino, C. Cara, A. Luridiana, A. Musinu, M. Casu, F. Secci and C. Cannas, Green Chem., 2018, Advance Article , DOI: 10.1039/C7GC02967E

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