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A catalyst-free, waste-less ethanol-based solvothermal synthesis of amides

Abstract

A green one-pot approach based on the solvothermal amidation of carboxylic acids with amines has been developed for the synthesis of diverse aliphatic and aromatic amides. It does not require the use of catalysts or coupling reagents and it occurs in the presence of ethanol that has been proved to have a key role in the process. The proposed strategy is extendable also to biologically active amides and could represent a low-cost and waste-less alternative to the common synthetic pathways.

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Publication details

The article was received on 02 Oct 2017, accepted on 01 Dec 2017 and first published on 04 Dec 2017


Article type: Communication
DOI: 10.1039/C7GC02967E
Citation: Green Chem., 2017, Accepted Manuscript
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    A catalyst-free, waste-less ethanol-based solvothermal synthesis of amides

    F. Dalu, M. A. Scorciapino, C. Cara, A. Luridiana, A. Musinu, M. Casu, F. Secci and C. Cannas, Green Chem., 2017, Accepted Manuscript , DOI: 10.1039/C7GC02967E

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