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Highly efficient synthesis of β-nitrate ester carboxamides through the ring-opening of 2-oxazolines

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Abstract

A novel method for the synthesis of β-nitrate ester carboxamides using non-corrosive tert-butyl nitrite (TBN) as the nitro source and easily available oxygen as the oxidant has been developed. Variously substituted 2-oxazolines were efficiently ring-opened to deliver the corresponding products in excellent yields. Notably, this reaction provides fast access to pharmaceuticals such as nicorandil.

Graphical abstract: Highly efficient synthesis of β-nitrate ester carboxamides through the ring-opening of 2-oxazolines

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Publication details

The article was received on 02 Sep 2017, accepted on 22 Nov 2017 and first published on 23 Nov 2017


Article type: Communication
DOI: 10.1039/C7GC02682J
Citation: Green Chem., 2017, Advance Article
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    Highly efficient synthesis of β-nitrate ester carboxamides through the ring-opening of 2-oxazolines

    K. Qiao, X. Yuan, L. Wan, M. Zheng, D. Zhang, B. Fan, Z. Di, Z. Fang and K. Guo, Green Chem., 2017, Advance Article , DOI: 10.1039/C7GC02682J

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