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Copper-catalyzed aerobic benzylic sp3 C–H oxidation mediated synthesis of 2,4,5-trisubstituted imidazoles via a domino multi-component reaction

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Abstract

An efficient and practical aerobic benzylic sp3 C–H oxidation as a key step towards the domino multi-component synthesis of 2,4,5-trisubstituted imidazoles has been reported. This green methodology employs an inexpensive catalytic copper/oxygen system and proceeds under mild reaction conditions. A variety of substituted imidazoles are prepared in moderate to excellent yields from α-methylene ketones using this innovative methodology.

Graphical abstract: Copper-catalyzed aerobic benzylic sp3 C–H oxidation mediated synthesis of 2,4,5-trisubstituted imidazoles via a domino multi-component reaction

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Publication details

The article was received on 14 Aug 2017, accepted on 12 Nov 2017 and first published on 14 Nov 2017


Article type: Paper
DOI: 10.1039/C7GC02484C
Citation: Green Chem., 2017, Advance Article
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    Copper-catalyzed aerobic benzylic sp3 C–H oxidation mediated synthesis of 2,4,5-trisubstituted imidazoles via a domino multi-component reaction

    J. Jayram and V. Jeena, Green Chem., 2017, Advance Article , DOI: 10.1039/C7GC02484C

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