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Tuneable 3D printed bioreactors for transaminations under continuous-flow

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Abstract

A method to efficiently immobilize enzymes on 3D printed continuous-flow devices is presented. Application of these chemically modified devices enables rapid screening of immobilization mechanisms and reaction conditions, simple transfer of optimised conditions into tailored printed microfluidic reactors and development of continuous-flow biocatalytic processes. The bioreactors showed good activity (8–20.5 μmol h−1 mgenz−1) in the kinetic resolution of 1-methylbenzylamine, and very good stability (ca. 100 h under flow).

Graphical abstract: Tuneable 3D printed bioreactors for transaminations under continuous-flow

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Publication details

The article was received on 09 Aug 2017, accepted on 03 Oct 2017 and first published on 03 Oct 2017


Article type: Communication
DOI: 10.1039/C7GC02421E
Citation: Green Chem., 2017, Advance Article
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    Tuneable 3D printed bioreactors for transaminations under continuous-flow

    E. Peris, O. Okafor, E. Kulcinskaja, R. Goodridge, S. V. Luis, E. Garcia-Verdugo, E. O'Reilly and V. Sans, Green Chem., 2017, Advance Article , DOI: 10.1039/C7GC02421E

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