Issue 23, 2017

Construction of the tetrahydroquinoline spiro skeleton via cascade [1,5]-hydride transfer-involved C(sp3)–H functionalization “on water”

Abstract

The pharmaceutically important tetrahydroquinoline spiro compounds were efficiently constructed via cascade SNAr/Knoevenagel condensation/[1,5]-hydride transfer/cyclization on water, featuring high atom-economy and step-economy. This water-based redox-neutral C(sp3)–H functionalization rendered a 4-step cascade reaction successful without resorting to any catalysts.

Graphical abstract: Construction of the tetrahydroquinoline spiro skeleton via cascade [1,5]-hydride transfer-involved C(sp3)–H functionalization “on water”

Supplementary files

Article information

Article type
Paper
Submitted
02 Aug 2017
Accepted
21 Oct 2017
First published
24 Oct 2017

Green Chem., 2017,19, 5653-5658

Construction of the tetrahydroquinoline spiro skeleton via cascade [1,5]-hydride transfer-involved C(sp3)–H functionalization “on water”

S. Zhu, C. Chen, M. Xiao, L. Yu, L. Wang and J. Xiao, Green Chem., 2017, 19, 5653 DOI: 10.1039/C7GC02353G

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