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Construction of the tetrahydroquinoline spiro skeleton via cascade [1,5]-hydride transfer-involved C(sp3)–H functionalization “on water”

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Abstract

The pharmaceutically important tetrahydroquinoline spiro compounds were efficiently constructed via cascade SNAr/Knoevenagel condensation/[1,5]-hydride transfer/cyclization on water, featuring high atom-economy and step-economy. This water-based redox-neutral C(sp3)–H functionalization rendered a 4-step cascade reaction successful without resorting to any catalysts.

Graphical abstract: Construction of the tetrahydroquinoline spiro skeleton via cascade [1,5]-hydride transfer-involved C(sp3)–H functionalization “on water”

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Publication details

The article was received on 02 Aug 2017, accepted on 21 Oct 2017 and first published on 24 Oct 2017


Article type: Paper
DOI: 10.1039/C7GC02353G
Citation: Green Chem., 2017, Advance Article
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    Construction of the tetrahydroquinoline spiro skeleton via cascade [1,5]-hydride transfer-involved C(sp3)–H functionalization “on water”

    S. Zhu, C. Chen, M. Xiao, L. Yu, L. Wang and J. Xiao, Green Chem., 2017, Advance Article , DOI: 10.1039/C7GC02353G

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