Issue 23, 2017

Visible-light-enabled spirocyclization of alkynes leading to 3-sulfonyl and 3-sulfenyl azaspiro[4,5]trienones

Abstract

A mild and convenient visible-light-induced method has been developed for the construction of 3-sulfonyl and 3-sulfenyl azaspiro[4,5]trienones through metal-free difunctionalization of alkynes with sulfinic acids or thiols at room temperature. The present protocol simply utilizes visible light as the safe and eco-friendly energy source, and inexpensive and non-toxic organic dyes (Eosin Y and Na2-Eosin Y) as photocatalysts providing various sulfur-containing azaspiro[4,5]trienones in moderate to good yields.

Graphical abstract: Visible-light-enabled spirocyclization of alkynes leading to 3-sulfonyl and 3-sulfenyl azaspiro[4,5]trienones

Supplementary files

Article information

Article type
Paper
Submitted
01 Aug 2017
Accepted
20 Oct 2017
First published
24 Oct 2017

Green Chem., 2017,19, 5608-5613

Visible-light-enabled spirocyclization of alkynes leading to 3-sulfonyl and 3-sulfenyl azaspiro[4,5]trienones

W. Wei, H. Cui, D. Yang, H. Yue, C. He, Y. Zhang and H. Wang, Green Chem., 2017, 19, 5608 DOI: 10.1039/C7GC02330H

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