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An environmentally benign and efficient synthesis of substituted benzothiazole-2-thiol, benzoxazole-2-thiol, benzimidazoline-2-thione in water

Abstract

An efficient and practical method for one-step synthesis of benzothiazole-2-thiols, benzoxazole-2-thiols and benzimidazoline-2-thione by cyclization of 2-aminothiophenols, 2-aminophenols, 1, 2-phenylenediamines with tetramethylthiuram disulfide (TMTD) in water was described. The features of this method include metal/ligand-free, exellent yield, short reaction time and broad substrate scope. The method provides a facile and convenient preparation of some potentially biologically active compounds.

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Publication details

The article was received on 31 Jul 2017, accepted on 12 Oct 2017 and first published on 13 Oct 2017


Article type: Paper
DOI: 10.1039/C7GC02311A
Citation: Green Chem., 2017, Accepted Manuscript
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    An environmentally benign and efficient synthesis of substituted benzothiazole-2-thiol, benzoxazole-2-thiol, benzimidazoline-2-thione in water

    Z. Dong, X. Liu, M. Liu, W. Xu, M. Zeng, H. Zhu and C. Chang, Green Chem., 2017, Accepted Manuscript , DOI: 10.1039/C7GC02311A

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