Jump to main content
Jump to site search


A base-free, ultrasound accelerated one-pot synthesis of 2-sulfonylquinolines in water

Author affiliations

Abstract

Without employing any base and organic solvent, an economical, practical and eco-friendly protocol has been developed for the one-pot synthesis of various functionalized 2-sulfonylquinolines from easily accessible starting materials in water under open-air conditions. Compared with conventional heating conditions, the use of ultrasound techniques not only improves the reaction efficiency and enhances the reaction rate but also minimizes the side reactions. This process has a broad substrate scope, mild reaction conditions, good yields, excellent chemo- and regioselectivities, operational simplicity, ease of scale-up and high energy efficiency. In addition, the process is remarkably greener than the previous routes with an atom economy of 70.7%, an E-factor of 1.17 and an eco-scale score of 71.

Graphical abstract: A base-free, ultrasound accelerated one-pot synthesis of 2-sulfonylquinolines in water

Back to tab navigation

Supplementary files

Publication details

The article was received on 29 Jul 2017, accepted on 16 Oct 2017 and first published on 16 Oct 2017


Article type: Paper
DOI: 10.1039/C7GC02304A
Citation: Green Chem., 2017, Advance Article
  •   Request permissions

    A base-free, ultrasound accelerated one-pot synthesis of 2-sulfonylquinolines in water

    L. Xie, Y. Li, J. Qu, Y. Duan, J. Hu, K. Liu, Z. Cao and W. He, Green Chem., 2017, Advance Article , DOI: 10.1039/C7GC02304A

Search articles by author

Spotlight

Advertisements