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Water excellent solvent for the synthesis of bifunctionalized cyclopentenones from furfural

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Abstract

Chiral cyclopentenones are important precursors in the asymmetric synthesis of target molecules. In particular, C-2 amino cyclopentenones could be utilised as intermediates towards antitumor natural products. On the basis of our previous experience, we report an environmentally friendly protocol for the synthesis of bifunctionalized cyclopentenones in water from furfural. The use of water and MW gives high regioselectivity and good to excellent yields. The reaction can be realized in short times with various nucleophiles.

Graphical abstract: Water excellent solvent for the synthesis of bifunctionalized cyclopentenones from furfural

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Publication details

The article was received on 29 Jul 2017, accepted on 15 Sep 2017 and first published on 15 Sep 2017


Article type: Paper
DOI: 10.1039/C7GC02303K
Citation: Green Chem., 2017, Advance Article
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    Water excellent solvent for the synthesis of bifunctionalized cyclopentenones from furfural

    M. Nardi, P. Costanzo, A. De Nino, M. L. Di Gioia, F. Olivito, G. Sindona and A. Procopio, Green Chem., 2017, Advance Article , DOI: 10.1039/C7GC02303K

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