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Isomerization of Glucose to Fructose catalyzed by Lithium Bromide in Water


This study demonstrated that glucose could be isomerized to fructose in the concentrated aqueous solution of lithium bromide (LiBr) under mild conditions. The isomerization mechanisms were studied via isotopic labeling experiments. It was found that both the cation (Li+) and the anion (Br‾) in the system catalyzed the isomerization of glucose to fructose. The Br‾ catalyzed the isomerization through the proton transfer mechanism via enediol intermediate, while the Li+ did through the intramolecular hydride shift mechanism from C2 to C1. The estimation using quantitative 13C-NMR analysis indicated that Br‾ catalyzed approximately 85% of the isomerization, while Li+ was responsible for the rest 15%. The results indicated that 31% of fructose was produced from glucose in LiBr trihydrate at 120 °C for 15 min. The outcomes of this study provided not only better understanding and insights of the sugar transformations in the LiBr solution but also an alternative approach to produce fructose from glucose.

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Publication details

The article was received on 15 Jul 2017, accepted on 03 Aug 2017 and first published on 03 Aug 2017

Article type: Paper
DOI: 10.1039/C7GC02145C
Citation: Green Chem., 2017, Accepted Manuscript
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    Isomerization of Glucose to Fructose catalyzed by Lithium Bromide in Water

    C. Yoo, N. Li, M. Swannell and X. Pan, Green Chem., 2017, Accepted Manuscript , DOI: 10.1039/C7GC02145C

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