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A practical synthesis of 2,3-dihydro-1,5-benzothiazepines

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Abstract

2,3-Dihydro-1,5-benzothiazepines have been obtained through a domino process involving a Michael addition of 2-aminothiophenols to chalcones, followed by in situ cyclization. Up to 98% chemical yields have been obtained at room temperature under essentially neutral conditions by using hexafluoro-2-propanol as an efficient medium.

Graphical abstract: A practical synthesis of 2,3-dihydro-1,5-benzothiazepines

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Publication details

The article was received on 11 Jul 2017, accepted on 27 Oct 2017 and first published on 30 Oct 2017


Article type: Paper
DOI: 10.1039/C7GC02097J
Citation: Green Chem., 2017, Advance Article
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    A practical synthesis of 2,3-dihydro-1,5-benzothiazepines

    D. C. M. Albanese, N. Gaggero and M. Fei, Green Chem., 2017, Advance Article , DOI: 10.1039/C7GC02097J

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