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An environmentally benign and selective electrochemical oxidation of sulfides and thiols in a continuous-flow microreactor

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Abstract

A practical and environmentally benign electrochemical oxidation of thioethers and thiols in a commercially-available continuous-flow microreactor is presented. Water is used as the source of oxygen to enable the oxidation process. The oxidation reaction utilizes the same reagents in all scenarios and the selectivity is solely governed by the applied potential. The procedure exhibits a broad scope and good functional group compatibility providing access to various sulfoxides (15 examples), sulfones (15 examples) and disulfides (6 examples). The use of continuous flow allows the optimal reaction parameters (e.g. residence time, applied voltage) to be rapidly assessed, to avoid mass- and heat-transfer limitations and to scale the electrochemistry.

Graphical abstract: An environmentally benign and selective electrochemical oxidation of sulfides and thiols in a continuous-flow microreactor

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Publication details

The article was received on 01 Jul 2017, accepted on 26 Jul 2017 and first published on 07 Aug 2017


Article type: Paper
DOI: 10.1039/C7GC01973D
Citation: Green Chem., 2017, Advance Article
  • Open access: Creative Commons BY license
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    An environmentally benign and selective electrochemical oxidation of sulfides and thiols in a continuous-flow microreactor

    G. Laudadio, N. J. W. Straathof, M. D. Lanting, B. Knoops, V. Hessel and T. Noël, Green Chem., 2017, Advance Article , DOI: 10.1039/C7GC01973D

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