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The continuous oxidation of HMF to FDCA and the immobilisation and stabilisation of periplasmic aldehyde oxidase (PaoABC)

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Abstract

By manipulating the reaction conditions, furandicarboxylic acid (FDCA) was prepared by the biooxidation of hydroxymethyl furfural (HMF) in a continuous one-pot reaction using galactose oxidase M3–5, periplasmic aldehyde oxidase (PaoABC), catalase and horseradish peroxidase. In addition, PaoABC was successfully entrapped in a SiO2 hydrogel and recycled 14 times without loss of activity. The catalyst was able to tolerate up to 200 mM DFF concentration giving FDCA in full conversion with very promising TOF and TON values.

Graphical abstract: The continuous oxidation of HMF to FDCA and the immobilisation and stabilisation of periplasmic aldehyde oxidase (PaoABC)

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Publication details

The article was received on 09 Jun 2017, accepted on 23 Aug 2017 and first published on 23 Aug 2017


Article type: Paper
DOI: 10.1039/C7GC01696D
Citation: Green Chem., 2017, Advance Article
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    The continuous oxidation of HMF to FDCA and the immobilisation and stabilisation of periplasmic aldehyde oxidase (PaoABC)

    S. M. McKenna, P. Mines, P. Law, K. Kovacs-Schreiner, W. R. Birmingham, N. J. Turner, S. Leimkühler and A. J. Carnell, Green Chem., 2017, Advance Article , DOI: 10.1039/C7GC01696D

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