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New insights into the catalytic reduction of aliphatic nitro compounds with hypophosphites under ultrasonic irradiation

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Abstract

This work describes an efficient process for the reduction of nitro compounds to the corresponding amines with a catalytic amount of Pd/C (0.6 mol%), and a mixture of sodium hypophosphite and hypophosphorous acid as a reducing agent in H2O/2-MeTHF at 60 °C. The reaction was optimized under silent conditions. The conditions for the in situ production of H2 using the mixture NaH2PO2/H3PO2 were studied. The influence of ultrasonic activation was investigated both in terms of efficiency and kinetics. The reaction was shown to be efficient in water, at 70 °C with a quantitative conversion and a maximal yield in only 15 min thanks to the ultrasonic activation. Finally, ultrasound was proved to act as a physical agent of phase transfer.

Graphical abstract: New insights into the catalytic reduction of aliphatic nitro compounds with hypophosphites under ultrasonic irradiation

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Publication details

The article was received on 02 Jun 2017, accepted on 14 Aug 2017 and first published on 14 Aug 2017


Article type: Paper
DOI: 10.1039/C7GC01622K
Citation: Green Chem., 2017, Advance Article
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    New insights into the catalytic reduction of aliphatic nitro compounds with hypophosphites under ultrasonic irradiation

    S. Letort, M. Lejeune, N. Kardos, E. Métay, F. Popowycz, M. Lemaire and M. Draye, Green Chem., 2017, Advance Article , DOI: 10.1039/C7GC01622K

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