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Issue 18, 2017
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Glucose promoted facile reduction of azides to amines under aqueous alkaline conditions

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Abstract

A quick and efficient method for the reduction of azides to amines in water using D-glucose and KOH as green reagents is reported. The protocol is simple, inexpensive, scalable, and can be applied to different aromatic, heteroaromatic and sulphonyl azides. A high level of chemoselectivity is observed for azide reduction in the presence of other reducible functionalities like cyano, nitro, ether, ketone, amide and acid. The reaction gets completed in a short time (5–20 minutes), and furnishes the amines in high yield (85–99%). Unlike conventional hydrogenations, this reduction protocol does not require any metal catalyst, elaborate experimental setup or use of high-pressure equipment.

Graphical abstract: Glucose promoted facile reduction of azides to amines under aqueous alkaline conditions

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Publication details

The article was received on 30 May 2017, accepted on 27 Jul 2017 and first published on 27 Jul 2017


Article type: Communication
DOI: 10.1039/C7GC01593C
Citation: Green Chem., 2017,19, 4268-4271
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    Glucose promoted facile reduction of azides to amines under aqueous alkaline conditions

    N. Chandna, F. Kaur, S. Kumar and N. Jain, Green Chem., 2017, 19, 4268
    DOI: 10.1039/C7GC01593C

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