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Issue 17, 2017
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Recent progress on fluorination in aqueous media

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Abstract

Advances in aqueous fluorination during the last few decades are summarized in this review. Fluorinated compounds have dominated a large percentage of agrochemicals and pharmaceuticals and a mass of functional materials. The incorporation of fluorine atoms into organic molecules has become one of the mainstream technologies for their functional modification. Water is very environmentally friendly and has advantageous physicochemical properties. Fluorination reactions in aqueous media are highly sought-after, and have attracted great attention in research areas ranging from medicinal chemistry to materials science. In early times and for a long time, fluorination was thought to be diametrically opposed to water or moisture. However, recent examples have conflicted with this viewpoint. The successful merger of “untamed” fluorine and “mild” water in chemical reactions has set up a new prospect for green chemistry. A considerable amount of remarkable research works have been carried out using water as a (co)solvent and/or a reactant for transformations including electrophilic, radical, or nucleophilic fluorination. We hope that this review will serve as a guide to better understand and to further broaden the field of fluorine chemistry in aqueous conditions.

Graphical abstract: Recent progress on fluorination in aqueous media

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Publication details

The article was received on 27 May 2017, accepted on 10 Jul 2017 and first published on 10 Jul 2017


Article type: Tutorial Review
DOI: 10.1039/C7GC01566F
Citation: Green Chem., 2017,19, 3951-3992
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    Recent progress on fluorination in aqueous media

    L. Yang, T. Dong, H. M. Revankar and C. Zhang, Green Chem., 2017, 19, 3951
    DOI: 10.1039/C7GC01566F

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