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An efficient approach for the synthesis of 5-hydroxy-chromeno[2,3-b]pyridines under catalyst and solvent free conditions

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Abstract

An efficient and sustainable method has been developed for the synthesis of novel 5-hydroxy-chromeno[2,3-b]pyridines by the reaction of 3-formylchromone, aromatic amines and malononitrile under catalyst and solvent-free conditions by simply stirring the components magnetically or by grinding at room temperature. Excellent yields, environmentally benign reaction conditions and easy workup are the advantages of this protocol. The structures have been established unambiguously.

Graphical abstract: An efficient approach for the synthesis of 5-hydroxy-chromeno[2,3-b]pyridines under catalyst and solvent free conditions

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Publication details

The article was received on 17 May 2017, accepted on 25 Jul 2017 and first published on 28 Jul 2017


Article type: Paper
DOI: 10.1039/C7GC01463E
Citation: Green Chem., 2017, Advance Article
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    An efficient approach for the synthesis of 5-hydroxy-chromeno[2,3-b]pyridines under catalyst and solvent free conditions

    S. Gupta and J. M. Khurana, Green Chem., 2017, Advance Article , DOI: 10.1039/C7GC01463E

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