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Issue 16, 2017
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One-pot and catalyst-free synthesis of pyrroloquinolinediones and quinolinedicarboxylates

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Abstract

A method for the catalyst-free synthesis of pyrroloquinolinediones and quinolinedicarboxylates is developed through a one-pot synthesis involving denitrogenation of azide, benzisoxazole formation, aza-Diels–Alder cycloaddition, and dehydrative aromatization. Only stoichiometric amounts of N2 and H2O are produced as by-products. A comprehensive green chemistry metrics analysis indicated that this method is much more efficient and greener than two reported methods for the synthesis of pyrroloquinolinediones.

Graphical abstract: One-pot and catalyst-free synthesis of pyrroloquinolinediones and quinolinedicarboxylates

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Publication details

The article was received on 10 May 2017, accepted on 07 Jul 2017 and first published on 07 Jul 2017


Article type: Paper
DOI: 10.1039/C7GC01380A
Citation: Green Chem., 2017,19, 3851-3855
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    One-pot and catalyst-free synthesis of pyrroloquinolinediones and quinolinedicarboxylates

    X. Zhang, G. Dhawan, A. Muthengi, S. Liu, W. Wang, M. Legris and W. Zhang, Green Chem., 2017, 19, 3851
    DOI: 10.1039/C7GC01380A

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