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Iridium-catalyzed highly efficient chemoselective reduction of aldehydes in water using formic acid as the hydrogen source

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Abstract

A water-soluble highly efficient iridium catalyst is developed for the chemoselective reduction of aldehydes to alcohols in water. The reduction uses formic acid as the traceless reducing agent and water as a solvent. It can be carried out in air without the need for inert atmosphere protection. The products can be purified by simple extraction without any column chromatography. The catalyst loading can be as low as 0.005 mol% and the turn-over frequency (TOF) is as high as 73 800 mol mol−1 h−1. A wide variety of functional groups, such as electron-rich or deficient (hetero)arenes and alkenes, alkyloxy groups, halogens, phenols, ketones, esters, carboxylic acids, cyano, and nitro groups, are all well tolerated, indicating excellent chemoselectivity.

Graphical abstract: Iridium-catalyzed highly efficient chemoselective reduction of aldehydes in water using formic acid as the hydrogen source

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Publication details

The article was received on 28 Apr 2017, accepted on 27 May 2017 and first published on 14 Jun 2017


Article type: Paper
DOI: 10.1039/C7GC01289F
Citation: Green Chem., 2017, Advance Article
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    Iridium-catalyzed highly efficient chemoselective reduction of aldehydes in water using formic acid as the hydrogen source

    Z. Yang, Z. Zhu, R. Luo, X. Qiu, J. Liu, J. Yang and W. Tang, Green Chem., 2017, Advance Article , DOI: 10.1039/C7GC01289F

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