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Heterogeneous C–H alkenylations in continuous-flow: oxidative palladium-catalysis in a biomass-derived reaction medium

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Abstract

Herein we report the unprecedented Fujiwara–Moritani reaction catalysed by the commercially available heterogeneous palladium catalyst Pd/C. The reaction works efficiently in GVL, a biomass derived solvent, in the coupling between variously substituted acetanilides and electron-poor alkenes, with complete selectivity towards the ortho-substitution. Moreover, the catalyst can be easily recycled and reused for consecutive reaction runs. We also developed a continuous-flow procedure, through an easily accessible tailor-made reactor, which allows the production of C–H alkenylated products on grams per hour scale.

Graphical abstract: Heterogeneous C–H alkenylations in continuous-flow: oxidative palladium-catalysis in a biomass-derived reaction medium

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Publication details

The article was received on 11 Apr 2017, accepted on 04 May 2017 and first published on 04 May 2017


Article type: Communication
DOI: 10.1039/C7GC01103B
Citation: Green Chem., 2017, Advance Article
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    Heterogeneous C–H alkenylations in continuous-flow: oxidative palladium-catalysis in a biomass-derived reaction medium

    F. Ferlin, S. Santoro, L. Ackermann and L. Vaccaro, Green Chem., 2017, Advance Article , DOI: 10.1039/C7GC01103B

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