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Synthesis of 2-Subsitituted Quinazolines by CsOH-Mediated Direct Aerobic Oxidative Cyclocondensation of 2-Aminoarylmethanols with Nitriles in Air

Abstract

By using air as the superior oxidant, a highly atom-efficient synthesis of 2-subsitituted quinazolines is developed by a CsOH-mediated direct aerobic oxidative reaction of the readily available and stable 2-aminoarylmethanols and nitriles. Effectively working as the promoter in the alcohol oxidation, nitrile hydration, and cyclocondesation steps, CsOH is the best base for the reaction. The similar method can also be extended to the synthesis of substituted quinolines starting from methyl ketones instead of nitriles.

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Publication details

The article was received on 30 Mar 2017, accepted on 12 May 2017 and first published on 15 May 2017


Article type: Communication
DOI: 10.1039/C7GC00977A
Citation: Green Chem., 2017, Accepted Manuscript
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    Synthesis of 2-Subsitituted Quinazolines by CsOH-Mediated Direct Aerobic Oxidative Cyclocondensation of 2-Aminoarylmethanols with Nitriles in Air

    S. Yao, K. Zhou, J. Wang, H. Cao, L. Yu, J. Wu, P. Qiu and Q. Xu, Green Chem., 2017, Accepted Manuscript , DOI: 10.1039/C7GC00977A

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