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Increasing global access to the high-volume HIV drug nevirapine through process intensification

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Abstract

Access to affordable medications continues to be one of the most pressing issues for the treatment of disease in developing countries. For many drugs, synthesis of the active pharmaceutical ingredient (API) represents the most financially important and technically demanding element of pharmaceutical operations. Furthermore, the environmental impact of API processing has been well documented and is an area of continuing interest in green chemical operations. To improve drug access and affordability, we have developed a series of core principles that can be applied to a specific API, yielding dramatic improvements in chemical efficiency. We applied these principles to nevirapine, the first non-nucleoside reverse transcriptase inhibitor used in the treatment of HIV. The resulting ultra-efficient (91% isolated yield) and highly-consolidated (4 unit operations) route has been successfully developed and implemented through partnerships with philanthropic entities, increasing access to this essential medication. We anticipate an even broader global health impact when applying this model to other active ingredients.

Graphical abstract: Increasing global access to the high-volume HIV drug nevirapine through process intensification

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Publication details

The article was received on 27 Mar 2017, accepted on 15 May 2017 and first published on 17 May 2017


Article type: Paper
DOI: 10.1039/C7GC00937B
Citation: Green Chem., 2017, Advance Article
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    Increasing global access to the high-volume HIV drug nevirapine through process intensification

    J. Verghese, C. J. Kong, D. Rivalti, E. C. Yu, R. Krack, J. Alcázar, J. B. Manley, D. T. McQuade, S. Ahmad, K. Belecki and B. F. Gupton, Green Chem., 2017, Advance Article , DOI: 10.1039/C7GC00937B

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