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Incorporation of carbon dioxide into phthalides via ligand-free copper-catalyzed direct carboxylation of benzoxasiloles

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Abstract

The direct carboxylation of benzoxasiloles with carbon dioxide proceeded smoothly under mild conditions using copper iodide as a catalyst to afford phthalides after an acid work-up. Broad substrate scope and application of this methodology for the synthesis of natural products highlight the synthetic utility of this protocol.

Graphical abstract: Incorporation of carbon dioxide into phthalides via ligand-free copper-catalyzed direct carboxylation of benzoxasiloles

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Publication details

The article was received on 25 Mar 2017, accepted on 17 Apr 2017 and first published on 18 Apr 2017


Article type: Communication
DOI: 10.1039/C7GC00917H
Citation: Green Chem., 2017, Advance Article
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    Incorporation of carbon dioxide into phthalides via ligand-free copper-catalyzed direct carboxylation of benzoxasiloles

    T. V. Q. Nguyen, J. A. Rodríguez-Santamaría, W. Yoo and S. Kobayashi, Green Chem., 2017, Advance Article , DOI: 10.1039/C7GC00917H

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