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Mechanoenzymatic peptide and amide bond formation

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Abstract

Mechanochemical chemoenzymatic peptide and amide bond formation catalysed by papain was studied by ball milling. Despite the high-energy mixing experienced inside the ball mill, the biocatalyst proved stable and highly efficient to catalyse the formation of α,α- and α,β-dipeptides. This strategy was further extended to the enzymatic acylation of amines by milling, and to the mechanosynthesis of a derivative of the valuable dipeptide L-alanyl-L-glutamine.

Graphical abstract: Mechanoenzymatic peptide and amide bond formation

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Publication details

The article was received on 27 Feb 2017, accepted on 28 Apr 2017 and first published on 02 May 2017


Article type: Paper
DOI: 10.1039/C7GC00615B
Citation: Green Chem., 2017, Advance Article
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    Mechanoenzymatic peptide and amide bond formation

    J. G. Hernández, K. J. Ardila-Fierro, D. Crawford, S. L. James and C. Bolm, Green Chem., 2017, Advance Article , DOI: 10.1039/C7GC00615B

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