Issue 9, 2017
From the journal:

Green Chemistry

Towards nitrile-substituted cyclopropanes – a slow-release protocol for safe and scalable applications of diazo acetonitrile†

Katharina J. Hock,a   Robin Spitznera  and  Rene M. Koenigs ORCID logo *a  

* Corresponding authors

a RWTH Aachen University, Institute of Organic Chemistry, Landoltweg 1, D-52074 Aachen, Germany
E-mail: rene.koenigs@rwth-aachen.de

Abstract

Diazo acetonitrile has long been neglected despite its high value in organic synthesis due to a high risk of explosions. Herein, we report our efforts towards the transient and safe generation of this diazo compound, its applications in iron catalyzed cyclopropanation and cyclopropenation reactions and the gram-scale synthesis of cyclopropyl nitriles.

Graphical abstract: Towards nitrile-substituted cyclopropanes – a slow-release protocol for safe and scalable applications of diazo acetonitrile

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Article information

DOI
https://doi.org/10.1039/C7GC00602K
Article type
Communication
Submitted
27 Feb 2017
Accepted
10 Apr 2017
First published
12 Apr 2017

Green Chem., 2017,19, 2118-2122

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Towards nitrile-substituted cyclopropanes – a slow-release protocol for safe and scalable applications of diazo acetonitrile

K. J. Hock, R. Spitzner and R. M. Koenigs, Green Chem., 2017, 19, 2118 DOI: 10.1039/C7GC00602K

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