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One-pot synthesis of 2-hydroxymethyl-5-methylpyrazine from renewable 1,3-dihydroxyacetone

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Abstract

An efficient and green method for the synthesis of 2-hydroxymethyl-5-methylpyrazine was achieved from biomass derived 1,3-dihydroxyacetone and diammonium phosphate via a one-pot reaction. The product yield was as high as 72% under optimized conditions of pH = 8.0–9.1 at 90 °C for 1 hour in a dioxane and water mixture as a solvent. A possible reaction mechanism was proposed according to the reaction kinetics, NMR and in situ ATR-IR characterization studies.

Graphical abstract: One-pot synthesis of 2-hydroxymethyl-5-methylpyrazine from renewable 1,3-dihydroxyacetone

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Publication details

The article was received on 24 Feb 2017, accepted on 26 May 2017 and first published on 26 May 2017


Article type: Communication
DOI: 10.1039/C7GC00578D
Citation: Green Chem., 2017, Advance Article
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    One-pot synthesis of 2-hydroxymethyl-5-methylpyrazine from renewable 1,3-dihydroxyacetone

    L. Song, M. Zheng, J. Pang, J. Sebastian, W. Wang, M. Qu, J. Zhao, X. Wang and T. Zhang, Green Chem., 2017, Advance Article , DOI: 10.1039/C7GC00578D

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