Jump to main content
Jump to site search


Mechanochemical indole synthesis by rhodium-catalysed oxidative coupling of acetanilides and alkynes under solventless conditions in a ball mill

Author affiliations

Abstract

A mechanochemical indole synthesis by rhodium(III)-catalysed C–H bond functionalisation in a planetary mill has been developed. It occurs in the absence of any solvent, does not require additional heating and only needs catalytic quantities of Cu(OAc)2 in combination with dioxygen as a terminal oxidant. Accordingly, the process represents a powerful and environmentally benign alternative to the common solution-based standard protocols.

Graphical abstract: Mechanochemical indole synthesis by rhodium-catalysed oxidative coupling of acetanilides and alkynes under solventless conditions in a ball mill

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 15 Feb 2017, accepted on 28 Apr 2017 and first published on 28 Apr 2017


Article type: Communication
DOI: 10.1039/C7GC00499K
Citation: Green Chem., 2017, Advance Article
  •   Request permissions

    Mechanochemical indole synthesis by rhodium-catalysed oxidative coupling of acetanilides and alkynes under solventless conditions in a ball mill

    G. N. Hermann, C. L. Jung and C. Bolm, Green Chem., 2017, Advance Article , DOI: 10.1039/C7GC00499K

Search articles by author