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Issue 11, 2017
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Mechanochemical indole synthesis by rhodium-catalysed oxidative coupling of acetanilides and alkynes under solventless conditions in a ball mill

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Abstract

A mechanochemical indole synthesis by rhodium(III)-catalysed C–H bond functionalisation in a planetary mill has been developed. It occurs in the absence of any solvent, does not require additional heating and only needs catalytic quantities of Cu(OAc)2 in combination with dioxygen as a terminal oxidant. Accordingly, the process represents a powerful and environmentally benign alternative to the common solution-based standard protocols.

Graphical abstract: Mechanochemical indole synthesis by rhodium-catalysed oxidative coupling of acetanilides and alkynes under solventless conditions in a ball mill

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Publication details

The article was received on 15 Feb 2017, accepted on 28 Apr 2017 and first published on 28 Apr 2017


Article type: Communication
DOI: 10.1039/C7GC00499K
Citation: Green Chem., 2017,19, 2520-2523
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    Mechanochemical indole synthesis by rhodium-catalysed oxidative coupling of acetanilides and alkynes under solventless conditions in a ball mill

    G. N. Hermann, C. L. Jung and C. Bolm, Green Chem., 2017, 19, 2520
    DOI: 10.1039/C7GC00499K

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