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Issue 7, 2017
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Tandem cyclisation of vinyl radicals: a sustainable approach to indolines utilizing visible-light photoredox catalysis

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Abstract

A tin-free method for the synthesis of substituted indolines has been developed generating vinyl radicals by visible-light-promoted photocatalysis in a reductive quenching cycle. This strategy offers a mild, robust, and high yielding pathway to a wide range of indolines containing diverse electronic substituents. The so obtained 2,3-disubstituted indolines serve as valuable precursors for the synthesis of biologically active molecules, which is demonstrated with the formal synthesis of tryptamines and furoindolines.

Graphical abstract: Tandem cyclisation of vinyl radicals: a sustainable approach to indolines utilizing visible-light photoredox catalysis

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Publication details

The article was received on 09 Feb 2017, accepted on 08 Mar 2017 and first published on 09 Mar 2017


Article type: Paper
DOI: 10.1039/C7GC00445A
Citation: Green Chem., 2017,19, 1721-1725
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    Tandem cyclisation of vinyl radicals: a sustainable approach to indolines utilizing visible-light photoredox catalysis

    S. K. Pagire and O. Reiser, Green Chem., 2017, 19, 1721
    DOI: 10.1039/C7GC00445A

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