Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance upgrade on Thursday 4th of May 2017 from 8.00am to 9.00am (BST).

During this time our websites will be offline temporarily. If you have any questions please use the feedback button on this page. We apologise for any inconvenience this might cause and thank you for your patience.



Regio- and stereoselective ring-opening reaction of spiro-epoxyoxindoles with ammonia under catalyst-free conditions

Author affiliations

Abstract

The regio- and stereoselective ring-opening of spiro-epoxyoxindoles with ammonia has been reported for the construction of 3-hydroxy-3-aminomethyloxindoles in high yields (up to 90%) and enantioselectivities (up to 99% ee) under mild and catalyst-free conditions. The reaction could be scaled up to the gram-scale and be used in the synthesis of analogues of dioxibrassinin and spirobrassinin.

Graphical abstract: Regio- and stereoselective ring-opening reaction of spiro-epoxyoxindoles with ammonia under catalyst-free conditions

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 09 Feb 2017, accepted on 31 Mar 2017 and first published on 03 Apr 2017


Article type: Communication
DOI: 10.1039/C7GC00438A
Citation: Green Chem., 2017, Advance Article
  •   Request permissions

    Regio- and stereoselective ring-opening reaction of spiro-epoxyoxindoles with ammonia under catalyst-free conditions

    B. Zhang, Y. Li, G. Bao, G. Zhu, J. Li, J. Wang, B. Zhang, W. Sun, L. Hong and R. Wang, Green Chem., 2017, Advance Article , DOI: 10.1039/C7GC00438A

Search articles by author