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Utility of iron nanoparticles and a solution-phase iron species for the N-demethylation of alkaloids

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Abstract

The N-demethylation of selected N-methylalkaloids using a modified Polonovski reaction can be accomplished using a novel green methodology employing nanoscale zero-valent iron, nZVI, in isopropanol. Use of nZVI promotes a much faster conversion to N-demethylated products due to much higher surface area on the metal surface as shown by SEM analysis. Rates of conversion can be further enhanced using catalytic quantities of the solubilised iron(0) species triiron dodecacarbonyl, Fe3(CO)12.

Graphical abstract: Utility of iron nanoparticles and a solution-phase iron species for the N-demethylation of alkaloids

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Publication details

The article was received on 08 Feb 2017, accepted on 05 May 2017 and first published on 09 May 2017


Article type: Paper
DOI: 10.1039/C7GC00436B
Citation: Green Chem., 2017, Advance Article
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    Utility of iron nanoparticles and a solution-phase iron species for the N-demethylation of alkaloids

    J. K. Awalt, R. Lam, B. Kellam, B. Graham, P. J. Scammells and R. D. Singer, Green Chem., 2017, Advance Article , DOI: 10.1039/C7GC00436B

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