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Direct conversion of γ,γ-dicarbonyl-substituted aldehydes into γ-lactones with a sodium chlorite/DBDMH combination

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Abstract

An unprecedented and challenging simultaneous carboxylation/halogenation, and next lactonization of γ,γ-dicarbonyl-substituted aldehydes has been realized using an eco-friendly, safe and inexpensive solid sodium chlorite (NaClO2)/1,3-dibromo-5,5-dimethyl-hydantoin (DBDMH) combination. This new reaction is amenable to a multi-gram scale-up with high yield.

Graphical abstract: Direct conversion of γ,γ-dicarbonyl-substituted aldehydes into γ-lactones with a sodium chlorite/DBDMH combination

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Publication details

The article was received on 13 Jan 2017, accepted on 08 May 2017 and first published on 09 May 2017


Article type: Communication
DOI: 10.1039/C7GC00144D
Citation: Green Chem., 2017, Advance Article
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    Direct conversion of γ,γ-dicarbonyl-substituted aldehydes into γ-lactones with a sodium chlorite/DBDMH combination

    Y. Guo, A. Xia, C. Meng, Z. Xu and D. Xu, Green Chem., 2017, Advance Article , DOI: 10.1039/C7GC00144D

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