Jump to main content
Jump to site search

Issue 2, 2017
Previous Article Next Article

Biocatalytic transamination with near-stoichiometric inexpensive amine donors mediated by bifunctional mono- and di-amine transaminases

Author affiliations

Abstract

The discovery and characterisation of enzymes with both monoamine and diamine transaminase activity is reported, allowing conversion of a wide range of target ketone substrates with just a small excess of amine donor. The diamine co-substrates (putrescine, cadaverine or spermidine) are bio-derived and the enzyme system results in very little waste, making it a greener strategy for the production of valuable amine fine chemicals and pharmaceuticals.

Graphical abstract: Biocatalytic transamination with near-stoichiometric inexpensive amine donors mediated by bifunctional mono- and di-amine transaminases

Back to tab navigation

Supplementary files

Publication details

The article was received on 29 Jul 2016, accepted on 12 Aug 2016 and first published on 12 Aug 2016


Article type: Communication
DOI: 10.1039/C6GC02102F
Citation: Green Chem., 2017,19, 361-366
  •   Request permissions

    Biocatalytic transamination with near-stoichiometric inexpensive amine donors mediated by bifunctional mono- and di-amine transaminases

    J. L. Galman, I. Slabu, N. J. Weise, C. Iglesias, F. Parmeggiani, R. C. Lloyd and N. J. Turner, Green Chem., 2017, 19, 361
    DOI: 10.1039/C6GC02102F

Search articles by author

Spotlight

Advertisements