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Issue 2, 2017
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Continuous flow biocatalysis: production and in-line purification of amines by immobilised transaminase from Halomonas elongata

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Abstract

The continuous flow synthesis of a series of amines was successfully achieved by exploiting the enhanced stability and broad substrate scope of an immobilised transaminase from Halomonas elongata (HEWT). A series of substrates were tested in flow reactors and transformed into the corresponding amines in good to excellent yields. The process was implemented with an integrated in-line purification step for the recovery of the pure amines.

Graphical abstract: Continuous flow biocatalysis: production and in-line purification of amines by immobilised transaminase from Halomonas elongata

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Publication details

The article was received on 29 Jun 2016, accepted on 03 Aug 2016 and first published on 03 Aug 2016


Article type: Communication
DOI: 10.1039/C6GC01780K
Author version available: Download Author version (PDF)
Citation: Green Chem., 2017,19, 372-375
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    Continuous flow biocatalysis: production and in-line purification of amines by immobilised transaminase from Halomonas elongata

    M. Planchestainer, M. L. Contente, J. Cassidy, F. Molinari, L. Tamborini and F. Paradisi, Green Chem., 2017, 19, 372
    DOI: 10.1039/C6GC01780K

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