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Evaluation of the in vivo acute antiinflammatory response of curcumin-loaded nanoparticles

Abstract

Curcumin is the main curcuminoid found in turmeric rizhomes being a strong candidate to formulate foodstuff with specific properties. Among its various bioactive properties, curcumin presents remarkable antiinflammatory activity, however, its low water solubility leads to low absorption. The improvement of its efficacy demands the development of new formulations, and encapsulation is a promising alternative. The objective of the present work was to obtain curcumin-loaded polyvinylpyrrolidone (PVP) nanoparticles and to evaluate the acute in vivo antiinflammatory activity. Nanoparticles were obtained by complexation using the solid dispersion technique and the characterization of the nanoparticles showed that curcumin and PVP formed an amorphous solid solution. Encapsulated curcumin was colloidally stable in distilled water which was attributed to the formation of hydrogen bonds between curcumin hydroxyl and PVP carbonyl groups. Rats were treated orally with single doses of curcumin and curcumin loaded PVP nanoparticles and the antiinflammatory activity was evaluated by an experimental model of carrageenan-induced paw edema, myeloperoxidase (MPO) activity and microcirculation in situ. Treatment with the nanoparticles at 12.5 mg/kg significantly reduced the intensity of edema and MPO activity while pure curcumin only presented significant effect at 400 mg/kg. Curcumin inhibited cell migration since rolling and adherent leukocytes were significantly reduced with nanoparticles at 50 mg/kg and with curcumin at 400 mg/kg. Encapsulated curcumin were effective at lower doses when compared to free curcumin and this may be due to the improved water affinity and colloidal stability of curcumin nanoparticles.

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Publication details

The article was received on 16 Oct 2017, accepted on 24 Nov 2017 and first published on 27 Nov 2017


Article type: Paper
DOI: 10.1039/C7FO01616F
Citation: Food Funct., 2017, Accepted Manuscript
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    Evaluation of the in vivo acute antiinflammatory response of curcumin-loaded nanoparticles

    M. Almeida, B. A. da Rocha, C. R. L. Francisco, C. G. Miranda, P. D. D. F. Santos, P. Araújo, C. Sayer, F. V. Leimann, O. H. Gonçalves and C. C.A. Bersani-Amado, Food Funct., 2017, Accepted Manuscript , DOI: 10.1039/C7FO01616F

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